Co-enzyme Q10 is a lipid soluble benzoquinone, which is an essential component of the mitochondrial membrane, and an intermediate between NADH or succinate dehydrogenase and cytochrome B in the human mitochrondrial respiratory chain.
It is involved in the manufacture of adenosine triphosphate (ATP), the basic energy molecule of the cell. It is found in the largest concentrations in the organs of the body that require the largest supply of energy such as the heart, the liver and the cells of the immune system.
Co-enzyme Q10 is a potent antioxidant. Studies have shown that the level of Co-enzyme Q10 in the tissues declines as we age, which can lead to reduced energy in the body.
There is evidence to suggest that Co-enzyme Q10 may play an important role in the maintenance of normal heart function by regulating the energy metabolism of the myocardium. It is excellent for oxygenating heart tissue, resulting in more efficient energy production and reduced cardiac stress.
It is a safe and effective treatment for angina and for many other heart conditions.
It has been shown to be effective in reducing blood pressure, although effect is not generally seen until after 2-3 months of usage. Dosage needs to be 90-100 mg daily for it to be effective.
See pages on ‘Angina’ and page on ‘Hypertension’
Co-enzyme Q10 is needed where people are taking statin type drugs as these cause a deficiency of Co-enzyme Q10. Other drugs such as beta-blockers, hypoglycaemics and anti-depressants can also inhibit the synthesis of Co-enzyme Q10.
Co-enzymesQ10 is also advised when using the natural alternatives to these drugs. Research has used levels of 100-300mg daily.
Deficiency of Coenzyme Q10 is a common finding in patients with hyperlipidaemia and this is believed to be a factor in oxidative damage found in tissues such as the arterial walls.
CoQ10 has been shown also to help reduce cholesterol levels and to prevent oxidation of LDL cholesterol.
In some cases Co-enzyme Q10 has been useful in reducing the side effects such as fatigue and general malaise that beta-blockers can cause.
In cases of severe periodontal disease improved healing has been reported when Co Q10 has been used at a daily dosage of 50mg.
There is also some evidence that high doses of Co-enzyme Q10 can have positive effects on Parkinson’s disease. (Studies have used doses up to 1200mg daily)
Co-enzyme Q10 has also been reported to be helpful in many other situations where energy production is low.
Diabetics have been seen to benefit from its use and in some cases it is thought to help over-weight people to loose weight more effectively.